LETTERS TO THE EDITOR

O-Nitration of Prostaglandins: Synthesis of 15-O-Nitrates of 11-Deoxyprostaglandin E₁ and Its Methyl Ester

I. V. Serkov* and V. V. Bezuglov**^#

^# Fax: +7 (095) 335-7103; e-mail: vvbez@oxylipin.ibch.ru

* Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow oblast, 142432 Russia

** Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997 Russia

O-Nitration of the allylic hydroxyl group in prostaglandins and the synthesis of 15-O-nitrates of 11-deoxyprostaglandin E₁ and its methyl ester are described for the first time.

Key words: nitration, nitric oxide, prostaglandins

Received August 23, 2005; in final form, September 5, 2005

Russian Journal of Bioorganic Chemistry 2006, 32 (1):99-101