Biological Activity and Pharmacological Prospects of Lupane Terpenoids : II. Semisynthetic Lupane Derivatives (Review)
T. G. Tolstikova a , I. V. Sorokina a , G. A. Tolstikov a , A. G. Tolstikov b # , and O. B. Flekhter c
#
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a
Vorozhtsov
Institute of Organic Chemistry,
Novosibirsk
, Siberian Division,
Russian
Academy
of Sciences, pr.
akademika
Lavrent'eva
9,
Novosibirsk
, 630090
Russia
b
Institute
of
Technical Chemistry
, Ural Division, Russian
Academy
of
Sciences
,
ul
.
Lenina
13a,
Perm
, 614990
Russia
c
Institute of Organic Chemistry,
Ufa
Scientific Center, Russian Academy of Sciences, pr.
Oktyabrya
71,
Ufa
, 450054 Russia
Received March 11, 2005; in final form, August 18, 2005
Abstract: The discussion of lupane triterpenoids as prospective medicinal preparations is continued, and semisynthetic triterpenoids are being discussed. Acyl derivatives that mainly exhibit high anti-HIV, antitumor, and organoprotective activities are described.
Key words: anti-HIV activity, betulin , betulinic acid, betulonic acid, cytostatic and organoprotective activities
Russian Journal of Bioorganic Chemistry 2006, 32 (3):261-276