The Synthesis of Arginine Derivatives of Chromone and Azauracil

A. A. Poyarkov , ^# M. S. Frasinyuk , V. K. Kibirev , and S. A. Poyarkova

^# Phone: (38044) 573-2728; e-mail: alexp@bpci.kiev.ua

Institute of Bioorganic Chemistry and Oil Chemistry, National Academy of Sciences of Ukraine , ul . Murmanskaya 1, Kiev , 02094 Ukraine

Received March 3, 2005; in final form, November 11, 2005

Abstract: The coupling of N-succinimide esters of 3-[7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-6-ethyl-4-oxo-4H-chromen-2-yl]propanoic acid and 5-carboxymethyl-6-azauracil with free arginine yielded the corresponding arginine derivatives, which were purified by crystallization. The structures of the compounds were confirmed by ¹H NMR spectroscopy.

Key words: arginine , azauracil , 7-hydroxychromone

Russian Journal of Bioorganic Chemistry 2006, 32 (3):277-279