BIOACTIVITY OF AVIPRIN AND AVIPRIN-3''-O-GLUCOSIDE, TWOLINEAR FURANOCOUMARINS FROM APIACEAE
© 2010 Seyed Mehdi Razavi*#, Gholamreza Zarrini**
*Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran; **Depatrment of Animal Sciences, Faculty of Natural Sciences, University ofTabriz, Tabriz, Iran
Recived October 20, 2009; in final form, November 19, 2009
Furanocoumarins are well-known natural products that occur in the most evolved genera of Apiaceae family. This compounds were found to have cytotoxic, phytotoxic, photosensitizing, insecticidal, antibacterial and high antifungal effects. Aviprin is considered as a linear furanocoumarin substituted at C8 with an oxygenated prenyl residue. In this study we found that aviprin is a bioactive compound that exhibits high antibacterial , antifungal and phytotoxic activity. The compound stunted the germination of seeds with IC50 value of 0.57 mg/mL. The compound also inhibited the mycelia growth of Sclerotinia sclerotiorum. Aviprin indicated antibacterial activity against tested gram negative and positive bacteria with inhibition zone of 19–23.5 mm. Our results shown that aviprin can play an allelopatic role for plant.
Key words: furanocoumarin, aviprin, allelochemicals, Sclerotinia sclerotiorum