STUDY OF SKIN ANTI-AGEING AND ANTI-INFLAMMATORY EFFECTS OF DIHYDROQUERCETIN, NATURAL TRITERPENOIDS, AND THEIR SYNTHETIC DERIVATIVES

© 2012 Chan Woo Lee^a, Nok Hyun Park^a, Jin Woong Kim^b,1 , Byung Hun Um^c, A. V. Shpatov^d, E. E. Shults^d, I. V. Sorokina^d and S. A. Popov^d,#

¹Phone: +82-31-400-5499; e-mail: kjwoong@hanyang.ac.kr
^#Phone: 8-383-330-67-48; e-mail: spopov@nioch.nsc.ru

^aAmore-Pacific Co. R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-Do, 446-729, Republic of Korea;
^bDept. of Applied Chemistry, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Kyeonggi-do, 426-791, Republic of Korea;
^cNatural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung 210-340, Gangwon-do, Republic of Korea;
^dNovosibirsk Institute of Organic Chemistry, Lavrentyev Ave. 9, Novosibirsk, 630090, Russian Federation

Abstract. Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituentss were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid).

Keywords: collagenase-1, triterpenoids, dihydroquercetin, photoageing, interleukin-8.