ECO-FRIENDLY SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITIES OF SOME NOVEL CHALCONES

© 2013 Salman A Khan^1,*, Abdullah M. Asiri^1,2, Khalid A. Alamry¹, Samy A. El-Daly¹, Mohie A. M. Zayed¹

*E-mail: sahmad_phd@yahoo.co.in

¹Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia;
²Center of Excellence for Advanced Materials Research, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

Received September 18, 2012; in final form December 7, 2012

Abstract: Chalcone derivatives have been synthesized by reaction of 1-(2,5-dimethyl-furan-3-yl)-ethanone with corresponding active aldehyde in ethanolic NaOH in microwave oven. The structure of these compounds was established by elemental analysis, IR, ¹H-NMR, ¹³C-NMR, and EI-MS spectral analysis. The anti-bacterial activity of these compounds was first tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined with the reference of standard drug Chloramphenicol. The results showed that pyrazol containing chalcone (compound 8) inhibited both types of bacteria (Gram-positive and Gram-negative) better than chloramphenicol.

Keywords: chalcones; anti-bacterial activity; Chloramphenicol

Биоорг.химия 2013, 39 (3): 353-357