SYNTHESIS AND SYNERGISTIC, ADDITIVE INHIBITORY EFFECTS OF NOVEL SPIRO DERIVATIVES AGAINST RINGWORM INFECTIONS

© 2013 Gajanand Sharma^a,#, Richa Sharma^b, Anshu Dandia^c, and Preeti Bansal^a

*E-mail: gnsharma2020@gmail.com

^aDepartment of Chemical Sciences, Suresh Gyan Vihar University , Jaipur
^bDepartment of Biotechnology and Food Science, Jayoti Vidyapeeth Women’s University, Jaipur
^cAnshu Dandia, Centre of Advanced Studies, Department of Chemistry, University of Rajasthan

Received May 14, 2012; in final form November 12, 2012

Abstract. An environmentally benign solvent free synthesis of various spiro-1,4-dihydropyridines (1,4-DHPs) incorporating 2-oxindole/piperidines is performed in 5-8 min with reasonable purity in 80-90% yield under microwave irradiation using montmorillonite KSF as an inorganic solid support. The reaction is found to be general with respect to various cyclic carbonyl compounds, e.g. cyclohexanone, substituted indole-2,3-dione, and piperidinone derivatives. In our study, these compounds were also found effective against dermatophytes and other fungal organisms. Our results suggest that novel spiro derivatives can be used for the treatment of dermatophytosis or ringworm infections.

Keywords: Montmorillonite KSF, microwave irradiation, MCRs, spiro-1,4-DHPs.

Биоорг.химия 2013, 39 (3): 358-368