SYNTHESIS OF NEW BENZOFURAN-1,3-THIAZOLIDIN-4-ONE DERIVATIVES FROM NATURAL SOURCES AND STUDY OF THEIR ANTIOXIDANT ACTIVITY

N. A. Abdel Latif^a,b,#, Sh. H. Abdel Hafez^a,c, and L. M. Break^a

^#Phone: 00966 530203556; e-mail: nehad_km@yahoo.com

^aChemistry Department, Faculty of Science, Taif University, Taif, KSA;
^bNatural Compounds Chemistry Department, Pharmaceutical Industries Division, National Research Center, Dokki, Egypt;
^cChemistry Department, Faculty of Science, Assuit university, Assuit, Egypt

Received November 12, 2012; in final form, January 14, 2013

Abstract. Synthesis of benzofuran-1,3-thiazolidinone derivatives is described herein. These compounds were prepared via a concise and short route by condensation reaction of khellinone with aromatic/aliphatic amines followed by cyclization using thioglycolic acid. The newly synthesized compounds were characterized using the well known spectroscopic tools (IR, ¹H NMR, and mass spectroscopy), as well as microanalysis. In frames of biological screening of the compounds, antioxidant activity was assessed in vitro.

Keywords: 1,3-thiazolidin-4-one, benzofuran, Schiff bases, anti-oxidant activity, khellinone, khellin.

Биоорг.химия 2013, 39 (4): 491-496