SYNTHESIS, INSECTICIDAL, AND FUNGICIDAL SCREENING OF SOME NEW SYNTHETIC QUINOLINE DERIVATIVES

© 2014 M. R. E. Alya^{b, #}, M. M. Ibrahima^c, A. M. Okael^d, Y. A. M. H. Gherbawy^{e, f}

^#Phone: +966 56 26 94 753; e-mail: mrea34@hotmail.com

^aChemistry Department, Faculty of Science, Taif University, AlhawyahTTaif, 888 Kingdom of Saudi Arabia;
^bChemistry Department, Faculty of Applied Science, Port Said University, Port Said, 42522 Egypt;
^cChemistry Department, Faculty of Science, Kafr El Sheikh University, Kafr El Sheikh, 33516 Egypt;
^dPlant Protection Research Institute, ARC, Dokki, Cairo, Egypt;
^eBiology Department, Faculty of Science, Taif University, AlhawyahTTaif, KSA;
^fBotany Department, Faculty of Science, South Valley University, Qena, Egypt

Received August 13, 2013; in final form, October 7, 2013

This paper describes the synthesis of a series of quinolines graphted with hydrazones, pyrazoles, pyridazine, phthalazine, triazepinone, semicarbazide, and thiomorpholide moieties and four metal complexes. These derivatives were screened against Fusarium oxysporum and the red palm weevil (RPW) Rhynchophorus ferrugineus Oliver (coleopteran: Curculionidae) as palm pathogens. Only chlorinated quinolines were active against these organisms with hydrazones being good fungicides, while those modified with pyrazoles and pyrazines showed moderate insecticidal activity. A unique trihydroxylated hydrazone was active against both organisms, while another hydrazone, the most potent fungicide in this series, exhibited insecticidal activity only upon complexation with Zn²⁺ ions.

Keywords: quinoline, hydrazones, fungicidal, insecticidal, red palm weevil.

Биоорг. химия 2014, 40 (2): 234-247