A CONVENIENT SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL THIENO[2,3-c]PYRAZOLE COMPOUNDS AS ANTIMICROBIAL AND ANTI-INFLAMMATORY AGENTS

© 2015 Adel M. Kamal El-Dean, Remon M. Zaki^#, Abdullah Y. Abdulrazzaq

^#E-mail: remonch2003@yahoo.com

Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt

Received April 3, 2014; in final form June 3, 2014

A new method for synthesizing 4-amino-3-methyl-1-phenyl-1H-5-substituted thieno[2,3-c]pyrazole was reported. The substituted groups at position 5 include carbonitrile, carboxamide, N-phenyl carboxamide, and benzoyl groups. The newly synthesized compounds and their derivatives were characterized by elemental analysis and spectroscopy (IR, ¹H NMR, and mass spectra). Furthermore, some of these synthesized compounds were screened against various pathogenic bacterial and fungal strains. The results demonstrate that most of the synthesized compounds possess a significant antibacterial activity against gram-positive and gram-negative bacteria. In addition, most of these compounds showed a remarkable anti-fungal activity. On the other hand, some of the synthesized compounds possess high anti-inflammatory activity, which was demonstrated using the carrageenan-induced rat paw edema assay.

Keywords: synthesis, reactions, thienopyrazole, thienopyrazolopyrimidine, thienopyrazoloimidazolopyrimidine.