IMIDAZO[4,5-a]QUININDOLINES AS HIGHLY EFFECTIVE ANTIBACTERIAL AGENTS

© 2016 Mehdi Pordel*^{, #}, Shirin Ramezani*, Maryam Jajarmi**, and Mina Sokhanvar*

^#Phone: +98 0513 8414182; fax: +98 0513 8424020; e-mail: mehdipordel58@mshdiau.ac.ir

*Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
**Khorasan Razavi Rural Water and Wastewater Co

Received May 20, 2015; in final form, August 28, 2015

Resistance to antimicrobial agents is a concern that exists globally and has a considerable impact on human and animal health, so that the discovery of new antibacterial compounds has become increasingly more important in combating infectious disease. In this paper, imidazo[4,5-a]quinindolines are introduced as new antibacterial agents against Gram-positive and Gram-negative bacteria. These pentacyclic compounds are synthesized by the reaction of N-alkyl-5-nitrobenzimidazoles with 2-(1-alkyl-1H-3-indolyl)acetonitrile under basic conditions in excellent yields. The structures of newly synthesized compounds were characterized by IR, ¹H NMR, ¹³C NMR, and mass spectral data. The antibacterial activities of the synthesized compounds were screened against standard strains of two Gram-positive and two Gram-negative bacteria using the broth microdilution method. Most of the compounds studied showed promising activities against both types of bacteria.

Keywords: 5-nitrobenzimidazoles, imidazo[4,5-a]quinindoline, Gram-positive and Gram-negative bacteria, antibacterial agents, MIC.

Биоорг. химия 2016, 42 (1): 117-121