ANTHELMINTIC AND ANTIBACTERIAL SCREENING OF A NEW SERIES OF N-[4-(4-NITROPHENOXY)PHENYL]-4-(SUBSTITUTED)-1,3-THIAZOL-2-AMINES

© 2016 Namratha Bhandari and Santosh L. Gaonkar^#

^#Phone: +91-9686605338; e-mail: gaonkarslg@rediffmail.com

Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal 576104, India

Received 18.06.2015; in final form, 26.10.2015

A series of N-[4-(4-nitrophenoxy)phenyl]-4-(substituted)-1,3-thiazol-2-amines was synthesized. Structural elucidation was accomplished by ¹H NMR, ¹³C NMR, IR, and elemental analyses of synthesized compounds. The title compounds were derived from 4-(4-nitrophenoxy)phenyl thiourea, which is the key intermediate in the synthesis of nitroscanate, an anthelmintic drug. Among the synthesized compounds, N-[4-(4-nitrophenoxy)phenyl]-4-(4-fluorophenyl)-1,3-thiazol-2-amine and N-[4-(4-nitrophenoxy)phenyl]-4-(4-methoxyphenyl)-1,3-thiazol-2-amine exhibited potent anthelmintic and antibacterial activities.

Keywords: anthelmintic activity, antibacterial activityl, nitroscanate, thiazole.

Биоорг. химия 2016, 42 (2): 233-237