MICROWAVE ASSISTED SYNTHESIS OF (E)-1-(2-((1-BENZYL-1H-1,2,3-TRIAZOL-4-YL)METHOXY)PHENYL)-3-(9-ETHYL-9H-CARBAZOL-3-YL)PROP-2-EN-1-ONES AND THEIR ANTIMICROBIAL ACTIVITY

© 2016 D. Ashok*^{, #}, S. Ravi*, B. Vijaya Lakshmi*, A. Ganesh*, and Shaik Adam**

^#Phone: 91-9391024769; e-mail: ashokdou@gmail.com

*Department of Chemistry, Osmania University, Hyderabad, 500007 India;
**Nanotechnology Laboratory, Regional Agricultural Research Station, ANGRAU, Tirupati, 517502 India

Received August 17, 2015; in final form, December 3, 2015

A novel series of 1,2,3-triazolo-carbazole chalcones were synthesized by the Claisen–Schmidt condensation reaction followed by the copper catalyzed Huisgen (2 + 3) cycloaddition reaction by conventional as well as microwave irradiation methods. The structures of the newly synthesized compounds were established on the basis of IR, ¹H NMR, ¹³C NMR, and mass spectral data. All the compounds were screened in vitro for antibacterial and antifungal activities.

Key words: carbazole chalcones, 1,2,3-triazoles, click reaction, microwave irradiation, antimicrobial activity.

Биоорг. химия 2016, 42 (3): 358-366