2016 Chang-Ik Choi*, 1, Hee Jeong Eom**, 1, and Ki Hyun Kim** , #

#Phone: 82-31-290-7700; fax: 82-31-290-7730; e-mail:

*College of Pharmacy, Dongguk University-Seoul, Goyang, 410-820 Republic of Korea;
**School of Pharmacy, Sungkyunkwan University, Suwon, 440-746 Republic of Korea

Received September 6, 2015; in final form , December 4, 2015

Lactuca indica L. (Compositae) has been used as a folk medicine for the treatment of intestinal disorders. Phytochemical constituents of L. indica were investigated, and their antioxidant and α-glucosidase inhibitory activities thoroughly studied. A phytochemical investigation of the aerial parts of L. indica resulted in the isolation and identification of eight phenolic compounds. The structures of the compounds were elucidated on the basis of spectroscopic evidence as apigenin, luteolin, isoquercitrin, chlorogenic acid, protocatechuic acid, p-hydroxymethyl benzoic acid, trans-cinnamic acid, and p-coumaric acid. Luteolin, isoquercitrin, chlorogenic acid, and p-hydroxymethyl benzoic acid showed antioxidant activities with IC50 values in the range of 35.552.5 μM. In addition, apigenin and luteolin showed α-glucosidase inhibition activities with IC50 values of 96.4 and 100.7 μM, respectively. These findings strongly suggest that L. indica is a potential source of natural antioxidants and/or anti-diabetic agents in pharmaceutical and health functional foods.

Keywords: Lactuca indica (Compositae), flavonoids, antioxidant, α-glucosidase inhibition.


1 The authors contributed equally to this work.

. 2016, 42 (3): 345-350