Ultrasonic-Assisted Synthesis of Pyrazolo[3,4-d]pyrimidin-4-ol Tethered with 1,2,3-Triazoles and Their Anticancer Activity
Prakash L. Kalavadiya, Vimal H. Kapupara, Dinesh G. Gojiya, Tejal D. Bhatt, Sanjay D. Hadiyal and Dr. Hitendra S. Joshi1
Department of Chemistry, Saurashtra University, Rajkot-360005, Gujrat, India
Received 23.12.2019; revised 11.03.2020; accepted 19.03.2020
Abstract––In the presents work synthesis and characterization of new heterocyclic derivatives containing pyrazolo[3,4-d]pyrimidine linkage with 1,4-disubstituted-1,2,3-triazoles via methylene-oxy group. The selected synthesized compounds were tested for their in-vitro anticancer activity against various cancer cell lines. Synthesis of compounds was done under ultrasonic-assisted Huisgen 1,3-dipolar cycloaddition reaction with good yields. Some of the newly synthesized compounds demonstrated good to moderate anticancer activity, most of compounds shows activity against renal cancer cell lines.
Keywords: Pyrazolo[3,4-d]pyrimidin-4-ol, 1,4-Disubstituted-1,2,3-triazole derivatives, In-vitro anticancer screening, Ultrasonic-assisted mild reaction conditions ________________________ Полный текст статьи печатается в переводной версии журнала Russian Journal of Bioorganic Chemistry, V.46, Issue 5, P. 803–813 (Springer).