O1igo( 2'-O-Methyl-Ribonucleotides) and their Derivatives. I. Automatic H- Phosphonate Synthesis of the Oligo ( 2'-O-Methylribonucleotides) via, H- Phosphonates

A.G. Venijaminova, Z. A. Kossolapova, M. N. Repkova

Institute of Bioorganic Chemistry, Siberian Division, Academy of Sciences of the USSR, Novosibirsk

Abstract: New representatives of the H-phosphonate's class, N-acyl-2'-O-methyl-5'-O-dime-thoxytritylribonucleoside 3'-H-phosphonates, were synthesized via salicylchlorophos-phine and used for the automatic synthesis of oligo(2'-O-methylribonucleotides). The efficiency of the method was demonstrated by the synthesis of a number of pyrimidine-ligomers with chain length from 6 to 15 monomers.

Russian Journal of Bioorganic Chemistry 1990, 16 (5):635-642

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