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Structural Organization of the [Met]enkephalin and Endorphins Molecules. II. Theoretical Conformational Analysis of α-, γ- and δ-endorphins
E. V. Suleimanova, N. M. God'jaev, N.A. Akhmedov, E. M. Popov
S. M. Kirov Azerbaijan State University, Baku, * Ail-Union Institute for Food Industry, Moscow
Abstract: Conformational energy calculations were carried out for neuropeptides α-, γ- and β-endorphins, which are 1—16, 1—17 and 1—19 fragments respectively, of β-endorphin. The proposed computational scheme yielded all possible low-energy conformational sets for these hormones. Specific features of spatial organization of each compound and similarities of their structures are discussed.
Russian Journal of Bioorganic Chemistry 1990, 16 (5):649-660