Synthesis of 5'-deoxynucleoside-5'-thiosulphuric acids of the purine series

L. V. Tsalmane, M. J. Lidak

Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, Riga

Abstract: The reaction of 5'-chloro-5'-deoxyadenosine, -inosine, -guanosine, -xanthosine and their 8-bromo- and 8-mercapto derivatives with sodium thiosulphate in the boiling aqueous solution was investigated. As a result, purine 5'-deoxynucleoside-5'-thiosul phuric acids and their 8-mercapto derivatives were obtained, and their conversion into 5'-mercapto-5'-deoxynucleosides was studied.

Russian Journal of Bioorganic Chemistry 1990, 16 (7):969-975

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