Structure of antitumour antibiotic variamycin

A. S. Shashkov, D. V. Jashunsky, Yu. V. Zhdanovich, G. B. Lokshin

N. D. Zelinsky Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow; All-Union Research Institute of Antibiotics, Moscow

Abstract: The results of the structural study of antitumour antibiotic variamycin and its peracetyl derivative by 1H-and 13C-NMR spectroscopy are reported.

Structures of carbohydrate chains of the antibiotics molecule are revised. Variamycin is shown to be 2-[β-cymmarosyl(1–3)-(β-oliosyl (1–3)-β-olivosyl]-6-[β-olivosyl (1–3)-β-olivosyl]chromomycinone.

Russian Journal of Bioorganic Chemistry 1991, 17 (3):410-416

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