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Peptides from Plasmodium falciparum proteins: synthesis and conjugation to proteins and synthetic carriers
B. B. Ivanov, V. V. Yurovsky, S. M. Tertyshnikova, T. M. Andronova, V. T. Ivanov
M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Moscow; Branch of M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Pushchino, Moscow Region
Abstract: To study coat proteins of Plasmodium falciparum, seven putative antigenic determinants of PMMSA, SHARP, GBP and four known determinants of CSP, CRA and RESA were synthesized. Computerized methods for predicting protein antigenic determinants were employed to select the peptides. For immunochemical studies the peptides were conjugated to proteins and synthetic carriers by means of nonspecific and regiospecific heterobifunctional reagents.
Russian Journal of Bioorganic Chemistry 1991, 17 (4):486-493